PCOS and Metformin (Or Glucophage)

Metformin or Glucophage is the most popular anti-diabetic drug taken by people all over the world. It has been shown to lower insulin levels in the blood. In other words, it increases the insulin sensitivity of a person and hence and your insulin secretion will be reduced. As the insulin starts to perform its job effectively, carbohydrates and fats are effectively converted into energy.

Metformin works by lowering the insulin levels, so it works only for PCOS patients with Insulin Resistance. People having PCOS due to other lifestyle issues need not have to use Metformin. Personally, I didn’t have Insulin Resistance and hence did not take this drug.

It is important to test for Insulin Resistance before you are prescribed this drug. If your doctor prescribes the drug without testing you for Insulin Resistance, I would recommend you to go for a second opinion.

If your family has as history of Diabetes, it is better to check for Insulin Resistance as Type2 diabetes is associated with early symptoms of Insulin Resistance.

The use of metformin in the treatment of PCOS is yet to be examined in large scale trials but a number of small scale studies have demonstrated a reduction of androgen and insulin levels and improvements in menstrual regularity and ovulation rates. Hence the drug should always be taken under the supervision of a gynaecologist or endocrinologist.

How Metformin Works

The exact action of Metformin is unknown though it has been proven to be beneficial for people with Insulin Resistance. It increases the insulin sensitivity by increasing the peripheral utilization of glucose. In a 2001 study, Metformin showed to stimulate the hepatic enzyme APMK, which plays an important role in the metabolism of fats and glucose. Your fats and carbohydrates are burnt effectively while you are on Metformin.

Side Effects

The most common side effect of Metformin is diarrhoea, cramps, nausea and vomiting. Metformin is more commonly associated with gastrointestinal side effects than other anti-diabetic drugs.

Side effects can cause severe discomfort for patients. It is most common when Metformin is first taken or when the dosage is significantly increased.

Who should take Metformin?

Because Metformin is primarily an anti-diabetic drug it can be taken by people who have Insulin Resistance. This will reduce the risk of acquiring Type 2 Diabetes in the future and will also reduce the symptoms associated with Insulin Resistance and PCOS.

PCOS Women trying to conceive are also treated with Metformin and in many cases Metformin along with food and life styles changes is shown to reduce the symptoms and bring back regular ovulation.

You can take Clomid along with Metformin if you are actively trying to conceive. But, it is better to start one medication and wait for at least 3 months to start on the other medication. This will help you to identify which medication actually works.

Women suspecting Insulin Resistance or women diagnosed with Insulin Resistance should talk to their doctor about Metformin and its possible use for you case.

Supplement with lifestyles Changes

If you have Insulin Resistance, following a healthy diet with regular exercise may benefit you. Healthy diet usually means with food with low Glycemic Index.